Abstract

Normah Awang¹, Nadia Atiqah Nordin², Nurlina Rashid² and Nurul Farahana Kamaludin²

DOI : http://dx.doi.org/10.13005/ojc/310138

Dithiocarbamates are a class of metal-chelating compounds with various applications in medicine. They have been used for the treatment of bacterial and fungal infections, possible treatment of AIDS, and most recently cancer. Dithiocarbamates are well-known compounds to bind strongly and selectively to many metal ions.Dithiocarbamateligands readily form chelates withmetal ions through its two donor sulphur atoms.A new series of plum bum(II) complexes with mixed ligands, dithiocarbamate, and 1,10-phenanthroline were successfully synthesised using in situ method. Microelemental analysis data of the complexes were in agreement with the general formula, Pb[S₂CNR’R”]₃phen (R’ = ethyl, R” = butyl, cyclohexyl; phen = 1,10-phenanthroline). Infrared spectra of the complexes showed that the thioureide ν(C-N) band was in the region 1450–1500 cm^-1. The unsplitting band of ν(C-S) in the region 930–1000 cm^-1indicatedthe bidentate nature of the chelated dithiocarbama to ligands. The ¹³C NMR chemical shift of the carbon atom of the N-CS₂ group appeared in the range of 202–207 ppm.

dithiocarbamate; thioureide; plumbum; chemical shift; phenanthroline

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