Abstract
Facially Selective Oxo-Diels-Alder Cycloadditions of α-Dienyl-β-Lactam: An Entry to Pyrano Tethered β-Lactams Bifunctional Hybrids
Maninderjeet Kaur Mann
, Rupesh Kumar* and Gaurav Bhargava
DOI : http://dx.doi.org/10.13005/ojc/380334
Abstract:
The functionalization of -lactams at C-3 position are useful for the strategic improvement in both the dimensions, namely synthetic utility, as versatile intermediate in organic synthesis and biological potential of these heterocyclic systems. The present manuscript involved the -facial selective synthesis -lactam hybrids employing highly regioselective and diastereoselective oxo-Diels–Alder reactions of diethyl ketomalonate with -dienyl--lactam with stereocentres at its - and - positions. This protocol provided the cycloaddition of - and - stereocentric diene with symmetrical heterodienophiles forming biologically potent regioselective and diastereoselective -lactams substituted pyrano bifunctional hybrids in good yields and -facially selectivity.
Keywords:Diastereoselective synthesis; β-lactams; Dienyl-β-lactams; π-facial selective synthesis; Regioselective synthesis
Back to TOC
A New Edition of Web of Science
Journal Impact Factor
2022: 0.5
Five Year: 0.8
Journal is Indexed in
Cabells Whitelist
