Abstract

Sadhana Dhondibhau Mhaske

DOI : http://dx.doi.org/10.13005/ojc/370412

Thiophene containing thiazolyl carbohydrazide on reaction with various aryl isothiocynates yields thiosemicarbazides which were transformed into 1,2,4- substituted thiazoles by Hantzsch synthesis and characterized by spectral methods. Most of the synthesized new thiosemicarbazides are found to be promisingly effective against tested bacterial strains and exhibited moderate activitytested fungal strains. Most of the 1, 2,4- substituted thiazoles are weakly active against test organisms.

Acid hydrazide; Antimicrobial Activity; Thiosemicarbazides; Thiazole

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