Abstract

Abeer A. El-Habeeb

DOI : http://dx.doi.org/10.13005/ojc/300402

New complexes of VO(II), Zn(II), Pd(II), Au(III) and Pt(IV) with atenolol (ATN) hypertensive drug ligand were synthesized and characterized by elemental analysis, conductometry, magnetic susceptibility, UV–Vis, IR, ESR, ¹H-NMR spectroscopy, X-ray diffraction analysis of powdered samples, scanning electron microscopy (SEM), and thermal analysis. The IR spectral data suggested that the ATN ligand behaves as a monobasic bidentate ligand towards the central metal ion with nitrogen atom of –NH secondary amine and the oxygen atom of –OH group after deprotonated. From the microanalytical data, the stoichiometry of the complexes 1:2 (metal: ligand) was found. The ligand and their metal complexes were screened for antibacterial activity against (Escherichia coli, and Staphylococcus aureus) and fungicidal activity against (Aspergillus flavus and Candida albicans). The Electrical conductivities of ATN and its metal complexes were also measured with DC electrical conductivity in the temperature range from room to 483 K.

Transition metals; Atenolol; Spectroscopic studies; Thermal analyses; DC electrical conductivity

[ View HTML Full Text]