Abstract

Hanan Alghamdi¹, Mohamed Abdelbaset^1,2 and Syed Nazreen¹

DOI : http://dx.doi.org/10.13005/ojc/360408

New Vanadium(V) complexes with new ligand 2-(4-((2-(carboxy) phenoxy) methyl)-1H-1,2,3-triazol-1-yl)benzoic acid (L₁) has been synthesized and characterized by different analytical techniques such as elemental analyzer, ¹H NMR, UV-Vis., IR, Mass spectrometry and thermal gravimetric analysis (TGA). The analytical data showed the stoichiometry of the Vanadium(V) to ligand was 1:1, and also indicated that the ligand (L₁) coordinate to the vanadium ions through oxygen and nitrogen atoms giving octahedral geometry. The ligands and their complexes have been examined for antimicrobial activity against four types of bacterial strains and one fungal strain. All the tested ligands and their complexes showed moderate to significant activity against Staphylococcus aureus, where the complex N(Pr)₄[VO(L₁)] (4) showed highest activity comparable to the standard drug, Amoxicillin. The other tested bacterial strains were resistant against the ligands and their complexes. The result of antifungal activity against the pathogenic fungi C. albicans indicated that the tested strain was resistant towards the ligand and its vanadium (V) complexes.

1,2,3-Triazole; Antimicrobial Activity; In Silico Pharmacokinetic; Vanadium Complex

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