Abstract

Lubna Swellmeen*¹, Amal Uzrail², Rand Shahin³ and Yusuf AL-Hiari⁴

DOI : http://dx.doi.org/10.13005/ojc/350401

Fluoroquinolones are well known to have an anti-infective action. In the present study we described the synthesis of novel florouquinolones derivative as antimicrobial agent. The biological test highlighted a good inhibitory activity for the 7-Chloro-1-Alkyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derived synthons especially against pathogenic Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Streptococcus agalactiae). The binding interactions were monitored and could explain the good inhibitory activity of the synthesized derivatives of florouquinolones.

Antibacterial activity; Florouquinolones derivatives; Gram-negative bacteria; Gram-positive bacteria

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