Abstract

Husam Hamza Salman*¹, Huda Salih Abood¹ and Usama Hamid Ramadhan²

DOI : http://dx.doi.org/10.13005/ojc/350251

This study included the preparation of a series of some new azo compounds by diazo coupling aromatic amines with salicylic acid derivatives. The prepared compounds identified using precise elemental analysis (C.H.N.), the results supported the structure of concerned compounds. The synthesized azo compounds also identified by using infrared spectroscopy and ¹H-NMR spectroscopy. Anti-inflammatory activity of the compounds were determined in-vitro by human red blood cell (HRBC) membrane stability method, the compounds showed a significant activity to protection of the cell membrane. Other compounds show moderate to low activity, sodium diclofenac was used as positive control.

Azo Compounds; In-Vitro Anti-Inflammatory and HRBC; Salicylic Acid

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