Abstract
A Novel Synthetic Route of Fused Tricyclic Framework Quinoline Derivatives from Readily Available Aliphatic Amino Carboxylic Acid Substrates
Shireen Mohammed
DOI : http://dx.doi.org/10.13005/ojc/350215
Abstract:
A novel and an efficient strategy of fused tricyclic quinoline heterocycle compounds from aliphatic amino carboxylic acid substrates is disclosed. The protocol here is proceed over main reaction processes including: cyclization, protection, amidine formation, further cyclization and finally coupling with boronic acid substrate through Suzuki reaction. These reactions afforded the corresponding products in high yields. Furthermore, all synthesized compounds were identiļ¬ed by spectral data.
Keywords:Aliphatic Amino Carboxylic Acid; Cross-Coupling Process; Cyclization; Diazotization; Nosylation Reactions, Palladium Catalyst; Protection Reactions; Suzuki Reaction
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