Abstract
Montmorillonite KSF Clay Catalyzed Microwave Synthesis of Novel Mannich Bases and Their Microbial Activity
R. Nandhikumar1,2 and K. Subramani1,3
DOI : http://dx.doi.org/10.13005/ojc/340328
Abstract:
Synthesis and characterization of N-(phenyl (thiomorpholino) methyl) acetamide (TBA), N-(phenyl (thiomorpholino) methyl) benzamide (TBB), N-(phenyl (thiomorpholino) methyl) nicotinamide (TBN) and 1-N-(phenyl (thiomorpholino) methyl) carbamide (TBC). The synthesized complexes have been characterized by elemental analysis, TLC, IR, 1H-NMR, 13C-NMR and Mass Spectroscopy. The final compounds were tested anti-microbial culture study. In the antibacterial and anti-fungal study the compounds 1-N-(phenyl (thiomorpholino) methyl) carbamide (TBC) shows very good activity against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli and N-(phenyl (thiomorpholino) methyl) acetamide (TBA) shows very good activity against Penicillium species, Candida albicans and Aspergillus Niger, compare to other Mannich bases. Small reaction time, eco-friendly products, high yield and very good microbial activity are the main advantages of this procedure which makes it more economical than the other conventional methods.
Keywords:Antibacterial; Antifungal; Mannich Base; Microwave
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