Abstract

Muhammad Nor Omar^1*, Nor Hazwani Mohd Hasali¹,  Helmi Yousif Alfarra¹, Mohd Ambar Yarmo² and  Ahmad Muzammil Zuberdi¹

DOI : http://dx.doi.org/10.13005/ojc/300315

Ethyl p-methoxycinnamate (EPMC), a major constituent of the Kaempferia galanga rhizome, was transformed  to ethyl p-hydroxycinnamate (EPHC) using  Aspergillus niger. The  EPHC metabolite was elucidated by NMR spectroscopic technique. Antimicrobial microbial study found that EPHC  was active against all strains tested with a good minimum inhibitory concentration (MIC). It was active  against both  Staphylococcus aureus and Bacillus cereus at MIC 333 µg/ml while against  Pseudomonas aeruginosa, Escherichia coli and Candida albicans at MIC 111 µg/ml.    It was also shown that  EPHC exhibited more growth inhibition potential than EPMC. Besides that,  EPHC has shown the minimum bactericidal concentration (MBC) toward B. cereus, P. aeruginosa and E. coli at the concentration of 1000 µg/mL while EPMC did not show killing potential toward the tested microorganisms.

Biotransformation; Kaempferia galanga Linn; Ethyl p-methoxycinnamate; Ethyl p- hydroxycinnamate; Aspergillus nige;, Antimicrobial

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