Abstract

Composite Film of Chitosan Loaded Norfloxacin With Improved Flexibility and Antibacterial Activity for Wound Dressing Application

Nor Jannah Mohd Sebri¹and Khairul Anuar Mat Amin^1,2

DOI : http://dx.doi.org/10.13005/ojc/330210

Abstract:

This research develops chitosan film incorporated norfloxacin (CH-NOR) designed to combat the infection of bacteria around the wound area. Inclusion of norfloxacin increased the strain-at-break or flexibility of the film. Swelling behavior and water vapor transmission rates (WVTRs) values are improved and optimum for CH-NOR1.0 film at 524 ± 65 % and 1916 ± 78 g m^-2 d^-1, respectively. In-vitro cell studies show that the present of norfloxacin in CH film gradually decreased the number of human dermal fibroblast cell (CRL2522, ATCC) after incubated for 72 hours. In-contrast, antibacterial activities of CH-NOR films exhibit strong inhibition zones against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria.

Keywords:

chitosan; norfloxacin; film, mechanical; biocompatibility; antibacterial

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