Abstract

Isolation of Lupeol, Design and Synthesis of Lupeol Derivatives and their Biological Activity

S. Devendra Rao¹, B. Nageswara Rao¹, P. Uma Devi² andA.Karteek Rao²

DOI : http://dx.doi.org/10.13005/ojc/330119

Abstract:

The triterpenoid, lupeol (1) has been isolated from the leaves extract of Walsura trifoliate. Few novel derivatives (4a–j) were synthesized from the naturally occurring lupeol (1) and confirmed by spectroscopic methods, and tested for antimicrobial and anti-proliferative activity against MDAMB-231, IMR32and A549 cell lines. This all compound showed moderate activities

Keywords:

Walsura trifoliata; Lupeol; oxime ester derivatives

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