Abstract

Construction and Performance Characterization of Ion Selective Electrodes for Potentiometric Determination of Citapolarm Hydrobromide in Biological Fluids

Amani S . Alturiqi^1,2, Samar O. Aljazzar^1,2, Reda A. Ammar^1,2 and Nuwair khalaf³

DOI : http://dx.doi.org/10.13005/ojc/330138

Abstract:

A coated-wire ion selective electrode based on ion-pair complex of citapolarm‎hydrobromide (CT)with sodium ‎tetraphenyl borate as electroactive material in the presence of dioctylphthalate (DOP)‎ as the plasticizing solvent mediatorwas prepared. The electrode displays Nernstian response of 56.83 mV/decade over the concentration range of 1.0×10^-6 to 1.0×10^-2mol/Lat 25 °C. The influence of membrane composition, pH of the ‎test solutionand foreign ions on the electrode wereinvestigated.‎ The electrode was successfully applied to determination of the drug in pure form, urine and serum‎by standard addition potentiometry.

Keywords:

Citapolarm‎hydrobromide‎(CT); Ion selective electrodes; potentiometry

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