Abstract

Omneya M. Khalil and Hanan M. Refaat

Eleven new 3-(4-bromophenyl)-5-(4-fluorophenyl)-2-pyrazoline derivatives 4-9 and 11-15 were synthesized by using 1-(4-bromophenyl)-3-(4-fluorophenyl) prop-2-en-1-one (3). The newly synthesized compounds were evaluated for anti-inflammatory activity against carrageenan edema in albino rats at a dose of 10 mg/kg. All the compounds of this series showed promising anti-inflammatory activity. The most active compound of this series, 7 was found to be most potent, which has shown higher percentage of inhibition of edema than the standard drug indomethacin.

Synthesis; 3, 5-diaryl-2-pyrazolines; Anti-inflammatory activity

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