Abstract

A.B. Patil

The interaction of Mn (II), Co (II), Ni (II), Cu (II) and Zn (II) metal ions with ampicillin (AMP) and cephalexin (CEP) have been studied by pH-metric technique at 0.1 M (KNO₃) ionic strength at 302 ± 0.5 K in aqueous medium. The data obtained were used to evaluate the values of proton-ligand and metal-ligand stability constants using Irving-Rossotti titration technique. Mixed ligand complex studies of these metal ions using aspartic acid (ASP) and glutamic acid (GLU) as primary ligands and AMP and CEP as secondary ligands also have been carried out pH-metrically at the same conditions.

Ternary complexes; Transition metal ions; ampicillin; aspartic acid and glutamic acid

[ View HTML Full Text]