Abstract

V. Naga Lakshmi¹, D.Ravi Kumar¹, S.V.M.Vardhan² and C.Rambabu²

Two simple and sensitive UV-Visible spectrophotometric methods A and B for the determination of tadalafil have been described. These methods are based on the formation of bluish green color and blue colored chromogens obtained when the drug was condensed with Isatin and Xanthydrol exhibiting lmax at 665 and 640nm respectively. These methods obey Beer’s Law in the concentration ranges of 0.4-2.0 and 4-20 μg/mL. The optimum conditions for all color development are described and the proposed methods have been successfully applied for the determination of tadalafil in bulk drug and pharmaceutical formulations. The common execipients and additives did not interfere in this method.

Tadalafil; chromogen; spectrophotometry; pharmaceutical

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