Abstract

B.C. Revanasiddappa* and E.V.S. Subrahmanyam

A new series of 1, 3, 4-oxadiazole (4a-4j) derivatives have been synthesized by oxidative cyclization of various INH hydrazones with chloramine – T as a powerful oxidizing agent. The INH hydrazones (3a-3j) in turn are obtained by the reaction of INH, with substituted aromatic aldehydes. The new products were characterized by special and analytical data. All the final synthesized compounds have been evaluated for their in-vitro antibacterial and antifungal activity. Some of the compound showed promising activity.

1, 3, 4-oxadiazoles; chloramine-T; hydrazones; antibacterial and antifungal activity

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