Abstract

Vetrivel Nadaraj¹* and Senniappan Thamarai Selvi²

The microwave synthesis of quinoline alkaloid 4-methoxyquinolin-2(1H)-one 3a and its analogues 3b-e was achieved in 8-11 minutes by methoxydechlorinated of 4-chloroquinolin-2(1H)-ones 2a-e using TBAB as phase transfer catalyst. The starting compound obtained by selective decholorination of 1a-e by sodium acetate/acetic acid and the structure of synthesized compound has been established by IR, 1H-NMR and Mass spectral data.

quinoline; alkaloids; acetic acid;L phase tranfer cataylst; microwave

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