Abstract

S.E.Bhandarkar

DOI : http://dx.doi.org/10.13005/ojc/300150

2-acetyl-1-naphthol 2 is prepared by Modified Nenchi’s method  which on treatment with furfuraldehyde and KOH gives 1-(1-hydroxy naphthalen-2-yl)-3-(furan-2-yl) prop-2-ene-1-ones 3 in excellent yield.  The chalcone 3 when subjected to  hydrazine / phenyl hydrazine/ semicarbazide / 2,4 dinitro phenyl hydrazine / isonicotinic acid hydrazide in  DMF solvent gives 3-(1-hydroxy naphthalene-2-yl)-5-(furan-2-yl)-1-substituted  pyrazolines 4, 5, 6, 7 and 8 in 35-45% yield. The structural assignments to the compounds 4, 5, 6, 7 and 8 are based on their elemental analysis and spectral data.

Synthesis; Characterization; Pyrazolines.

[ View HTML Full Text]