Abstract

Syed Adnan Ali Shah ^1,2*, Sadia Sultan ultanultan ^1,2 and Humera Syed Adnan ³

DOI : http://dx.doi.org/10.13005/ojc/290201

Biocatalysis is also widely applicable for enhancement of bioprocess productivity, selectivity of target reactions and production of valuable pharmaceutical ingredients, precursors and key intermediates. Microorganisms and cell suspension cultures of plant have found wide application in biotransformations of steroidal drugs in order to obtain high regio- and stereoselective products. Studies of steroid modifications catalyzed by microbial or plant cell cultures represent a well-established research approach and methodology in white biotechnology. Bioconversion can be done at the position of steroid molecule hardly available for chemical agents; functionalization of the molecule can be performed stereospecifically; several reactions can be completed in one biotechnological step.

Steroidal drugs; Microbial transformation; Hydroxylation; Whole-cell biocatalysis; Plant cell cultures

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