Abstract

Muhammad Nor Omar^1*, Nor Hazwani Mohd Hasali¹ and Mohd Ambar Yarmo²

DOI : http://dx.doi.org/10.13005/ojc/320547

The extraction of Kaempferiagalanga rhizome using steam distillation and supercritical fluid extraction (SFE) carried out. After fractionation, the major compound of the K. galanga, ethyl p-methoxycinnamate (EPMC) was Aspergillus ethyl p-hydroxycinnamate (EPHC). The biological activity of EPMC and its biotransformed product (EPHC) established by activity on human breast cancer (MCF-7) cell line using MTT assay. Ethyl p-hydroxycinnamate (EPHC) was most cytotoxic at 1000 μg/mL  percentage cell viability was 9.87% IC₅₀ was 340μg/mL. showed slight cytotoxicity activity compared to EPMC.   that the biotransformation process was able to produce metabolite (EPHC) higher cytotoxicity activity compared to its parent compound (EPMC).

Kaempferiagalanga; ethyl p-methoxycinnamate

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