Abstract

Islam H. El Azab^1,2,*, Laila M. Break¹ and Zainah A. A. El-Zahrani¹

DOI : http://dx.doi.org/10.13005/ojc/320514

We herein reported the utility of 3-(3-(dimethylamino)acryloyl)-2H-chromen-2-one (2), as a versatile precursor for the synthesis of some new azole systems of possible biological activities. The structure of the newly synthesized compounds has been confirmed by IR, ¹H NMR, mass spectral and elemental analysis. Furthermore, some selected compounds were screened in vitro for their anti-microbial activities. The results declared that most of the synthesized compounds have high anti-microbial activity.

2H-Chromen-2-one; dimethyformamide-dimethylacetal; enaminone, azole; anti-microbial activity

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