Abstract

Nitinkumar S. Shetty¹, Nadaf Y. F.², Dinesh Bilehal³, Shyamkumar V.⁴ and Santosh L. Gaonkar^1,*

DOI : http://dx.doi.org/10.13005/ojc/320544

The paper describes industrially scalable synthesis and single crystal studies of 3-cyclopropyl-3,4-dihydroquinazolin-2(1H)-one4, a versatile intermediate in the synthesis of number of biologically active compounds. The target compound has been characterized by LC-MS, ¹H NMR and IR. The crystal structure analysis shows that the title compound crystallizes in monoclinic classunder the space groupP 1 21/n 1with cell parameters, a = 10.273(2) Å, b = 8.3227(19) Å, c = 11.623(3) Å, β = 104.980(3)°, V = 960.0(4) ųand Z=4.

N,N'-carbonyldiimidazole; 3-cyclopropyl-3, 4-dihydroquinazolin-2(1H)-one

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