Abstract

G. Rajendran* and A. Abhilasha

Dioxouranium (VI) complexes of istin-3- thiosemicarbazone were synthesized and characterized by IR spectra, UV- visible spectra, molar conductance, elemental analysis and thermal analysis. Istin-3- thiosemicarbazone acts as a powerful chelating agent coordinating through the oxygen, nitrogen and sulphur atoms of carbonyl, azomethine and thioketo groups respectively. Various anions such as acetate, lactate, nitrate, perchlorate, sulphate and thiocyanate act as secondary ligands by coordinating to the metal ion. Mixed ligand complexes with dimethyl sulfoxide and diphenyl thiourea have also been synthesized and characterized. The ligand and some of the complexes were assessed for their antimicrobial activity towards Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans and Cryptococcus neoformans.

Dioxouranium; Isatin-3-thiosemicarbazone; dimethylsulfoxide; diphenylthiourea; antimicrobial activity

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