Abstract

J. J. Modha, N. J. Dutta, J. M. Parmar and H. H. Parekh*

The target compounds 2-aroylhydrazino-6-p-chlorophenyl-5-cyano-3-N-methyl-4(3H)-pyrimidinone (4a-o) has been synthesized by the condensation of 6-p-chlorophenyl-5-cyano-2-hydrazino-3-N-methyl-4(3H)-pyrimidinone 3 with different aroyl chlorides. All the products have been evaluated for their antimicrobial activity towards different strains of bacteria and fungi and antitubercular activity towards mycobacterium tuberculosis H37 Rv.

4-(3H)-pyrimidinones; antimicrobial activity; antitubercular activity

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