ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of l-(Arylformamidino)-l-(2-Pyridyl 2-thiazolyl) thiocarbamide hydrochlorides and their local anaesthetic and antifungal activity

B. N. Singh

Sri Baldeo Degree College, Baragaon, Varanasi India.

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ABSTRACT:

1 -Arylformamidino-1 -(2-Pyridyl/2-thiazolyI) thiocarbamide hydrochlorides have been synthesized and screened for their local anaesthetic and antifungal activity. Compound 1-(Phenylformamidino) -1 -(2-pyridyI) thiocarbamide hydrochloride was high potent local anaesthetic. In the antifungal testing there was complete inhibition of growth of Altemaria alternata and Curvuiaria lunata at 0.025 gm/100 ml concentration by 1-(Phenyl formamidino)-1-(2-Pyridyl) thiocarbamide hydrochloride and encouraging results were obtained with other compounds. These compounds have also been oxidised to five 4-(2-pyridyl)- 3-aryl -imino-5-imino 1,2,4-thiadiazolidines.

KEYWORDS:

Hydrochlorides; Antifungal; Anaesthetic

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Singh B. N. Synthesis of l-(Arylformamidino)-l-(2-Pyridyl 2-thiazolyl) thiocarbamide hydrochlorides and their local anaesthetic and antifungal activity. Orient J Chem 1993;9(2).


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Singh B. N. Synthesis of l-(Arylformamidino)-l-(2-Pyridyl 2-thiazolyl) thiocarbamide hydrochlorides and their local anaesthetic and antifungal activity. Orient J Chem 1993;9(2). Available from: http://www.orientjchem.org/?p=38322



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