Behaviour of 5, 6-Diphenyl-4-Carbethoxy 2,3-Dihydropyridazin 3- one, Towards Some Different Nucleophiles

Amina. Afify, A. A. El-Khamry, A.Y. Soliman, M. A. Saved and E. A. Kassab

Department of Chemistry, Faculty of Science, Ain Shams University, Cairo Egypt.

ABSTRACT:

The hithertounknown 4- carbethoxy-5,6-diphenyl-2,3-dihydropyridazin-3-one (II) has been synthesized via cyclisation of diethyl-∝ -benzoylhydrazone-benzil malonate (I), which has been prepared on condensation of benzil monohydrazone with diethyl malonate. (II) reacted with primary amines, as well as, secondary amines producing (lll)a-g and/or (IV)a & b respectively. With some different Grignard reagents as carbon nucleosphiles, (II) reacted affording (V)a & b. (II), also, underwent hydroxy methylation on its reaction with form aldehyoe to give (VI), while, under -went complete Mannich reaction with formaldehyde and secondary amines providing (Vll)a & b.

KEYWORDS:

Towards; Different; Nucleophiles

Download this article as: 

Copy the following to cite this article: Afify A, El-Khamry A. A, Soliman A. Y, Saved M. A, Kassab E. A. Behaviour of 5, 6-Diphenyl-4-Carbethoxy 2,3-Dihydropyridazin 3- one, Towards Some Different Nucleophiles. Orient J Chem 1988;4(4).

Copy the following to cite this URL: Afify A, El-Khamry A. A, Soliman A. Y, Saved M. A, Kassab E. A. Behaviour of 5, 6-Diphenyl-4-Carbethoxy 2,3-Dihydropyridazin 3- one, Towards Some Different Nucleophiles. Orient J Chem 1988;4(4). Available from: http://www.orientjchem.org/?p=42070