Reaction of 2-Styryl-Quinazoline-4-Ones With Tetra-Chloro-o-Benzoquinone : Synthesis of -1, 4-Benzodioxins and -4, 5-Ortho Phenylenedioxy-Quinazolone Derivatives of Bactericidal and Fungicidal Activity

Khairy A. M. El-Bayouki¹, H. H. Moharram¹*, Ali S. El-Sayed²**, H. M. Hosney¹ and M. Abdel Hamid³

¹National Research Centre, Dokki, Cairo, Egypt ²Institute For Drug Research and Control, Cairo, Egypt ³Faculty of Science, Al-Azhar University, Nasr-City, Cairo, Egypt

ABSTRACT:

2-styryl-quinazolones 2 a-j are obtained by condensation of 2-methyl-3 (aryl)-4 (1H) quinazolones 1 with different aldehydes. Thermal reaction of tetrachloro-o-benzoquinone with compounds 2 a-g yielded the "Michael adducts" 1, 4-benzodioxins 3. However, the quinone with compounds 2 h-j, is found to undergo selective cyclo-addition to the 4, 5 C-C double bond of the furyl moiety and thus yielding the ortho-phenylenedioxy-stryrylquinazoIones 4, I. R., u. v., and 1Hnmr spectral determinations for the synthesized products are discussed.

KEYWORDS:

Tetra-Chloro-o-Benzoquinone; Phenylenedioxy-Quinazolone

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Copy the following to cite this article: El-Bayouki K. A. M, Moharram H. H, El-Sayed A. S, Hosney H. M, Hamid M. A. Reaction of 2-Styryl-Quinazoline-4-Ones With Tetra-Chloro-o-Benzoquinone : Synthesis of -1, 4-Benzodioxins and -4, 5-Ortho Phenylenedioxy-Quinazolone Derivatives of Bactericidal and Fungicidal Activity. Orient J Chem 1988;4(1).

Copy the following to cite this URL: El-Bayouki K. A. M, Moharram H. H, El-Sayed A. S, Hosney H. M, Hamid M. A. Reaction of 2-Styryl-Quinazoline-4-Ones With Tetra-Chloro-o-Benzoquinone : Synthesis of -1, 4-Benzodioxins and -4, 5-Ortho Phenylenedioxy-Quinazolone Derivatives of Bactericidal and Fungicidal Activity. Orient J Chem 1988;4(1). Available from: http://www.orientjchem.org/?p=41897