Nitrogen Heterocyclic Analogous of Cannabinoids - Part III. Synthesis of 10a-11 -Etheno -6H-Indolo [1,2-C] [1,3] Benzoxazine System and Studies of Antibacterial, Antifungal and Toxico- Logical Activities

Suresh C. Sharma

Department of Chemistry, Meerut College, Meerut-250 001 India.

ABSTRACT:

6,6-Dimethyl-10a, 11- etheno-10-hydroxy-6H-indolo [1,2-C] [1,3] benzoxazine was synthesised by starting from hydroquinone. The latter was methylated and then subjected to succinoylation, clemmensen's reduction and cyclization to produce 5,8—dimethoxy—1—keto—1,2,3,4—tetraphydra* naphthalene, which on Fischer indole synthesis with phenylhydrazine afforded 1,4—dimethoxy 5,6— dihydrobenyo [a] carbazole, this on aromarization, dimethylation and treatment with acetone in presence of p — toluene sulphonyl chloride afforded the title compound. The structures were elucidated by elemental and IR spectral analysis. The compound secreened for antibacterial activity against E. coli and S. aureus and for antifungal activity against H. sativum and A. alternate. The toxicity was tested on white mice.

KEYWORDS:

Antibacterial; Antifungal; Logical Activities.

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Copy the following to cite this article: Sharma S. C. Nitrogen Heterocyclic Analogous of Cannabinoids - Part III. Synthesis of 10a-11 -Etheno -6H-Indolo [1,2-C] [1,3] Benzoxazine System and Studies of Antibacterial, Antifungal and Toxico- Logical Activities. Orient J Chem 1986;2(1).

Copy the following to cite this URL: Sharma S. C. Nitrogen Heterocyclic Analogous of Cannabinoids - Part III. Synthesis of 10a-11 -Etheno -6H-Indolo [1,2-C] [1,3] Benzoxazine System and Studies of Antibacterial, Antifungal and Toxico- Logical Activities. Orient J Chem 1986;2(1). Available from: http://www.orientjchem.org/?p=42374