Zn[(L)-proline]2: A Novel and Recyclable Catalyst for the Synthesis of 2-Aryl-4(3H)-quinazolinones in Solvent-Free Conditions

Naser Montazeri¹*, Khalil Pourshamsian¹, Mahdi Fouladi² and Masoud Bayazi¹

¹Department of Chemistry ,Tonekabon Branch, Islamic Azad University, Tonekabon (Iran).

²Islamic Azad University, Tonekabon Branch, Young Researchers Club, Tonekabon (Iran).

ABSTRACT:

An efficient, solvent-free and facile synthesis of 3-aryl quinazolinones from cyclocondensation of 2-aminobenzamides with aryl aldehydes catalyzed by Zn[(L)-proline]2 in the presence of CuCl2 is described. The salient features of the reaction include good yields , mild reaction conditions , low loading of catalyst , and operational simplicity. The catalyst is reusable and can be applied several times without considerable decrease in the yields and rates of the reactions.

KEYWORDS:

2-Aryl quinazolinones; Zn[(L)-proline]2; Solvent-free Conditions; Recyclable Catalyst

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Copy the following to cite this article: Montazeri N, Pourshamsian K, Fouladi M, Bayazi M. Zn[(L)-proline]2: A Novel and Recyclable Catalyst for the Synthesis of 2-Aryl-4(3H)-quinazolinones in Solvent-Free Conditions. Orient J Chem 2012;28(1).

Copy the following to cite this URL: Montazeri N, Pourshamsian K, Fouladi M, Bayazi M. Zn[(L)-proline]2: A Novel and Recyclable Catalyst for the Synthesis of 2-Aryl-4(3H)-quinazolinones in Solvent-Free Conditions. Orient J Chem 2012;28(1). Available from: http://www.orientjchem.org/?p=25586