Synthesis and Antifungal Activities of 2-Hydroxy-4,6-Substituted Phenyl Pyrimidine

S. K. Datir, P. S. Bhodke and U. E. Choudhari

Department of Chemistry, Mahatma Fule Mahavidyalaya, Warud - 444 906 (India).

ABSTRACT:

Flavones and chromanones are known to be biologically important compounds over 4000 chemically unique flavanoids have been identified in plant sources. These low-molecular-weight substances, found in all vascular plants, with an assortment of basic structure of phenyl benzopyrones (phenyl chromones). In the present work 2-hydroxy pyrimidine and 2-mercapto pyrimidine were prepared from phenol i.e. o-chlorophenol as a starting material. The compounds were characterized on the basis of elemental analysis their IR, ¹HNMR and screened for their antifungal activity. Some of these compounds showed significant antifungal activity. The activity was correlated with the structure.

KEYWORDS:

Chalcone; Pyrimidine; Antifungal activity

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Copy the following to cite this article: Datir S. K, Bhodke P. S, Choudhari U. E. Synthesis and Antifungal Activities of 2-Hydroxy-4,6-Substituted Phenyl Pyrimidine. Orient J Chem 2011;27(4).

Copy the following to cite this URL: Datir S. K, Bhodke P. S, Choudhari U. E. Synthesis and Antifungal Activities of 2-Hydroxy-4,6-Substituted Phenyl Pyrimidine. Orient J Chem 2011;27(4). Available from: http://www.orientjchem.org/?p=24361