"On Water" Organic Synthesis: One pot Facile Regioselective Synthesis of (1E,4E)-1,5-bis-aryl-penta-1, 4-dien-3-ones using an Alternative Precursor

N.O. Mahmoodi*, M. Mamaghani and A. Azimi

Synthesis Research Laboratory, Department of Chemistry, Faculty of Science,  University of  Guilan, PO Box 41335-1914, Rasht (Iran).

Corresponding Author E-mail: Mahmoodi@guilan.ac.ir

ABSTRACT:

One-pot synthesis of a series of (1E,4E)-1,5-bis-arylpenta-1,4-dien-3-ones considering as curcumin analogs through the condensation of pentane-2,4-dione with aldehydes in water and base for the fast (5-8min) and high yielding (85- 95%)preparation of dienone systems such as 7a-g are enclosed. The structures of the products were deduced from their elemental analyses and spectroscopic data.

KEYWORDS:

On water; One pot; regioselective; (1E,4E)-1,5-bis-aryl-penta-1,4-dien-3-ones

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Copy the following to cite this article: Mahmoodi N. O, Mamaghani M, Azimi A. "On Water" Organic Synthesis: One pot Facile Regioselective Synthesis of (1E,4E)-1,5-bis-aryl-penta-1, 4-dien-3-ones using an Alternative Precursor. Orient J Chem 2011;27(4).

Copy the following to cite this URL: Mahmoodi N. O, Mamaghani M, Azimi A. "On Water" Organic Synthesis: One pot Facile Regioselective Synthesis of (1E,4E)-1,5-bis-aryl-penta-1, 4-dien-3-ones using an Alternative Precursor. Orient J Chem 2011;27(4). Available from: http://www.orientjchem.org/?p=24174