Development of a Temperature - Sensitive Composite Hydrogel for Drug Delivery Applications

Mohammad Sadeghi¹* and Mojgan Yarahmadi²

¹Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, Arak (Iran). ²Department of English, Humaniti Faculty, Islamic Azad University, Arak Branch, Arak (Iran).

ABSTRACT:

To develop materials with improved controll ability and specificity, we have investigated synthesis of composite hydrogels with temperature-sensitive properties using thermal cross-linking, Specifically in the presence of kaolin powder. my novel composite materials are composed of particles made of kappa-carrageenan-poly(N-isopropylacrylamide) (PNIPAAm), temperature sensitive hydrogels, and a thermal cross linker, methylene bisacrylamide (MBA). A proposed mechanism for hydrogel composite formation was suggested and Infrared spectroscopy was carried out to confirm the chemical structure of the composite. Moreover, morphology of the samples was examined by scanning electron microscopy (SEM). The effect of MBA concentration and temperature of reaction on the water absorbency capacity has been investigated. The swelling variations of hydrogels were explained according to swelling theory based on the hydrogel chemical structure. The hydrogels exhibited tem-sensitivity and cation exchange properties. The temperature- and pH reversibility properties of the hydrogels make the intelligent polymers as good candidates for considering as potential carriers for bio active agents, e.g. drugs.

KEYWORDS:

Superabsorbent Hydrogel; kappa-carrageenan; Acrylic monomers; composite

Download this article as: 

Copy the following to cite this article: Sadeghi M, Yarahmadi M. Development of a Temperature - Sensitive Composite Hydrogel for Drug Delivery Applications. Orient J Chem 2011;27(3).

Copy the following to cite this URL: Sadeghi M, Yarahmadi M. Development of a Temperature - Sensitive Composite Hydrogel for Drug Delivery Applications. Available from: http://www.orientjchem.org/?p=11723