Estimation of Etoricoxib in Tablet Dosage form by RP- HPLC using Internal Standard with Emphasize on Specificity Parameter Method

S.B. Bagade, D.B. Meshram and M.R. Tajne

¹SVKM’s NMIMS, School of Pharmacy & Management Technology, Babulde, Bank of Tapi River, Mumbai-Agra Road, Shirpur Campus, Dist.Dhuley - 425 405, India. ²Department of Pharmaceutical Sciences, R. T. M. Nagpur University Campus, Nagpur - 440 033, India.

ABSTRACT:

A simple, precise and rapid RP-HPLC method was developed for the estimation of etoricoxib in pharmaceutical dosage forms. The method was carried out on a ODS Hypersil C₁₈ (250 x 4.6 mm) column using a mixture of acetonitrile: water (55:45 v/v). The detection was carried out at 269 nm using caffeine as an internal standard. The linearity was found to be 10 to 60μg/ml injection with correlation coefficient of 0.999. The percentage recovery was found to be 99.24± 1.064 to 102.66±1.22. The result of analysis of marketed formulation was found to be 99.09±0.473 to 99.55±0.493%. The method was validated and studied for the various parameters like accuracy, precision, ruggedness and specificity study . The proposed method was successfully applied for the estimation of etoricoxib in pharmaceutical dosage forms.

KEYWORDS:

Etoricoxib; HPLC; Pharmaceutical dosage forms.

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Copy the following to cite this article: Bagade S. B, Meshram D. B, Tajne M. R. Estimation of Etoricoxib in Tablet Dosage form by RP- HPLC using Internal Standard with Emphasize on Specificity Parameter Method. Orient J Chem 2011;27(2).

Copy the following to cite this URL: Bagade S. B, Meshram D. B, Tajne M. R. Estimation of Etoricoxib in Tablet Dosage form by RP- HPLC using Internal Standard with Emphasize on Specificity Parameter Method. Available from: http://www.orientjchem.org/?p=24948