Synthesis and anticonvulsant activity of new 3’-aryl- 7-bromo-spiro[ [1]benzothiophene-3,2’-[1,3] thiazolidine]-2,4’-dione derivatives

Ashraf F. Zaher, Nadia A. Khalil and Eman M. Ahmed

Department of Organic Chemistry, Faculty of Pharmacy, Cairo University, Cairo (Egypt).

ABSTRACT:

Two series of spiro[ [1]benzothiophene-3,2'-[1,3]thiazolidine]-2,4'-diones 5a-e and 6a-e were synthesized, characterized and evaluated for anticonvulsant activity. Reaction of [1]benzothiophene-2,3-dione (3) with certain arylamines afforded the corresponding Schiff bases 4a-e. Cyclization of 4a-e with thioglycolic or thiolactic acids brought about the target spiro compounds 5a-e and 6a-e respectively. Spectral data, IR and 1 H-NMR proved that the structure of the spiro compounds 5a-e and 6a-e might be in a mixture of two forms or derivatives of [1,3]thiazolidinone and / or hydroxy[1,3]thiazole. The final compounds were tested for their anticonvulsant activity.

KEYWORDS:

Anticonvulsant activity; epilepsy and drug therapy

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Copy the following to cite this article: Zaher A. F, Khalil N. A, Ahmed E. M. Synthesis and anticonvulsant activity of new 3’-aryl- 7-bromo-spiro[ [1]benzothiophene-3,2’-[1,3] thiazolidine]-2,4’-dione derivatives. Orient J Chem 2010;26(4).

Copy the following to cite this URL: Zaher A. F, Khalil N. A, Ahmed E. M. Synthesis and anticonvulsant activity of new 3’-aryl- 7-bromo-spiro[ [1]benzothiophene-3,2’-[1,3] thiazolidine]-2,4’-dione derivatives. Available from: http://www.orientjchem.org/?p=11596