Validated Spectrophotometric Estimation of Esomeprazole using Hydrotrophic Solubilisation Technique
Ar. Magesh*, R. Vijayalakshmi, D. Satyavati , G. Sravanthi Devi and M.D. Dhanaraju
Research Lab, GIET School of Pharmacy, NH-5 Chaitanya Nagar, Rajahmundry - 533 294 (India).
A Simple, accurate and reproducible spectrophotometric method by Hydrotrophic Solubilisation was developed for the estimation of Esomeprazole. In the present investigation, hydrotropic solution of urea (10M) was employed as a solubilising agent to solubilise the poorly water soluble drug, esomeprazole in the tablet form and determined with the help of spectrophotometric determination in ultraviolet region. Esomeprazole showed maximum absorption at 301 nm and obeyed Beer’s law in concentration range of 10-50μg/ml. Statistical analysis of the result has been carried out revealing high accuracy and good precision.
KEYWORDS:Esomeprazole; hydrotropy; spectrophotometry; urea
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| Copy the following to cite this article: Magesh A, Vijayalakshmi R, Satyavati D, Devi G. S, Dhanaraju M. D.Validated Spectrophotometric Estimation of Esomeprazole using Hydrotrophic Solubilisation Technique. Orient J Chem 2010;26(3). |
| Copy the following to cite this URL: Magesh A, Vijayalakshmi R, Satyavati D, Devi G. S, Dhanaraju M. D.Validated Spectrophotometric Estimation of Esomeprazole using Hydrotrophic Solubilisation Technique. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=24673 |
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