ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of (7-Methoxynaphthalen-2-Yl(Amino Methyl) -1,3,4-Thiadiazol-2-Yl) Phenylazetidin -2-One as Anti-Inflammatory Agents

S. Kumar, A. Kumar, G. Chikara, G. Kumar, P. Kumar, R. kumar, N. Shisodia, B.P. Yadav & Y.P. Garg

Department of Chemistry Meerut College Meerut (India).

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ABSTRACT:

N-benzylidene-5-(7-methoxynaphthalene-2-ylamino)methyl)-1,3,4-thiadiazol-2-amine(4a-4e), 3-(5-(7-methoxynaphthalen-2-ylamino)methyl)-1,3,4-thiadiazol-2-yl)-2-phenyl thia-zolidin-4-one (5a-5e) and 3-chloro-1-(5-((7-methoxynaphthalen-2-yl amino)methyl)-1,3,4-thiadiazol-2-yl)-4-phenylazetidin-2-one (6a-6e) have been synthesized in present study. The structures of these newly synthesized compounds were confirmed by their analytical and spectral data. These compounds were also evaluated for their anti-inflammatory, analgesic activities. The compound (6e) was found to exhibit potent anti-inflammatory activity as compared to the standard drugs phenylutazone. The structures of all compounds have been evaluated by elemental and spectral analysis.

KEYWORDS:

Naphthalene derivatives; anti-inflammatory; analgesic activities

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Kumar S, Kumar A, Chikara G, Kumar G, Kumar P, kumar R, Shisodia N, Yadav B. P, Garg Y. P. Synthesis of (7-Methoxynaphthalen-2-Yl(Amino Methyl) -1,3,4-Thiadiazol-2-Yl) Phenylazetidin -2-One as Anti-Inflammatory Agents. Orient J Chem 2010;26(3).


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Kumar S, Kumar A, Chikara G, Kumar G, Kumar P, kumar R, Shisodia N, Yadav B. P, Garg Y. P. Synthesis of (7-Methoxynaphthalen-2-Yl(Amino Methyl) -1,3,4-Thiadiazol-2-Yl) Phenylazetidin -2-One as Anti-Inflammatory Agents. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=24339



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