Synthesis and in vitro anticancer activity of some organotin(IV) benzoate compounds

Sutopo Hadi* and Mita Rilyanti

Department of Chemistry, University of Lampung Bandar, Lampung 35145 (Indonesia).

ABSTRACT:

We have prepared a series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate compounds by the reaction of the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoic acid. The compounds synthesized were characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies, and are based on the microanalytical data. The in vitro activity showed that triphenyltin(IV) benzoate synthesized exhibit higher antitumor than those of dibutyltin(IV) and diphenyltin(IV) analogous.

KEYWORDS:

Synthesis; organotin(IV) benzoate; anticancer

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Copy the following to cite this article: Hadi S, Rilyanti M. Synthesis and in vitro anticancer activity of some organotin(IV) benzoate compounds. Orient J Chem 2010;26(3).

Copy the following to cite this URL: Hadi S, Rilyanti M. Synthesis and in vitro anticancer activity of some organotin(IV) benzoate compounds. Available from: http://www.orientjchem.org/?p=11566