Spectrophotometric method for the determination of amorolfine

A. APARNA*, B. ANUPAMA , G. VINDYA and G. DEVALA RAO

K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada - 520 010 (India).

ABSTRACT:

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Amorolfine (AMF) in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with 3-methyl 2-benzothiazolinone hydrazone(MBTH λmax 660 nm). The absorbance of the colored species is measured against the corresponding reagent blank. Method B is based on oxidation followed by complex formation when the drug reacts with ferric chloride and 1,10- phenanthroline (λmax 510nm) .These methods have been statistically evaluated and found to be precise and accurate.

KEYWORDS:

Spectrophotometry, Amorolfine, pharmaceutical dosage form.

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Copy the following to cite this article: APARNA A, ANUPAMA B, VINDYA G, RAO G. D. Spectrophotometric method for the determination of amorolfine. Orient J Chem 2010;26(3).

Copy the following to cite this URL: APARNA A, ANUPAMA B, VINDYA G, RAO G. D. Spectrophotometric method for the determination of amorolfine. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=29698