Spectrophotometric Method for the Determination

A. Aparna*, B. Anupama , G. Vindya and G. Devala Rao

K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Vijayawada - 520 010 (India).

ABSTRACT:

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Amorolfine (AMF) in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with 3-methyl 2-benzothiazolinone hydrazone(MBTH lmax 660 nm). The absorbance of the colored species is measured against the corresponding reagent blank. Method B is based on oxidation followed by complex formation when the drug reacts with ferric chloride and 1,10-phenanthroline (lmax 510nm) .These methods have been statistically evaluated and found to be precise and accurate.

KEYWORDS:

Spectrophotometry; Amorolfine; pharmaceutical dosage form

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Copy the following to cite this article: Aparna A, Anupama B, Vindya G, Rao G. D. Spectrophotometric Method for the Determination. Orient J Chem 2010;26(3).

Copy the following to cite this URL: Aparna A, Anupama B, Vindya G, Rao G. D. Spectrophotometric Method for the Determination. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=24698