New Spectrophotometric Methods for the Determination of Amisulpride in Pharmaceutical Dosage forms

E. Venumadhav¹, T. Neetha², P. Bhargavi², and G. Ramana²

¹Cheif Operating Officer, Veeda CR, Ahmedabad (India). ²K.V.S.R. Siddhartha College of Pharmaceutical Science, Vijayawada - 520 010 (India).

ABSTRACT:

Three simple and sensitive visible spectrophotometric methods (A, B, & C) for the determination of Amisulpride in bulk and pharmaceutical dosage forms are described. They are based on the formation of coolred species by treatig its diazotized product with Bratton-Marshall (B.M.) reagent (method A; lmax 525 nm) or pure drug with 3-methyl-2-benzothiazolinone hydraze hydrochloride (MBTH) in the presence of Ferric chloride (method B; lmax 580 nm) or with Folin-Ciocalteau phenol's reagent under alkaline conditions (method C; lmax 625 nm) . These methods were extended to the analysis of pharmaceutical formulation and result compared with the reference method.

KEYWORDS:

Spectrophotometry; amisulpride; pharmaceutical formulations

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Copy the following to cite this article: Venumadhav E, Neetha T, Bhargavi P, Ramana G. New Spectrophotometric Methods for the Determination of Amisulpride in Pharmaceutical Dosage forms. Orient J Chem 2010;26(3).

Copy the following to cite this URL: Venumadhav E, Neetha T, Bhargavi P, Ramana G. New Spectrophotometric Methods for the Determination of Amisulpride in Pharmaceutical Dosage forms. Orient J Chem 2010;26(3). Available from: http://www.orientjchem.org/?p=24651