ISSN : 0970 - 020X, ONLINE ISSN : 2231-5039
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Synthesis of Hydroxy Propyloximino-1-Benzoyl- Indole-2-One Derivatives as Antibacterial and Antifungal Activities

Harcharan Lal1, T. P. Aggarwal1, V. P. Singh and Ashok Kumar2

1Department of Chemistry K.G.K P.G College Moradabad (India). 2Medicinal Chemistry Division, Department of Pharmacology L.L.R.M. Medical College, Meerut - 25 004 (India).

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ABSTRACT:

1-Benzoyl indole-2,3-dione (1)1-Benzoyl-3-oximindole-2-one (2) 3-(2', 3'-Epoxypropyloximino)-1-benzoyl indole-2-one (3) 3-(3'-Substituted phenyl-2'-hydroxy propyloximino)-1- benzoyl indole-2-ones (4-8) 3-(3'-Substituted trizzolo-2'-hydroxy propyloximino-1-benzoyl indole-2-ones (9-10) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 10 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole. The structure of all newly hydroxy propyloximino derivatives were confirmed on the basis of spectral and analytical data

KEYWORDS:

Hydroxy propyloximino Derivatives; Antibacterial and Antimicrobial activities

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Lal H, Aggarwal T. P, Singh V. P, Kumar A. Synthesis of Hydroxy Propyloximino-1-Benzoyl- Indole-2-One Derivatives as Antibacterial and Antifungal Activities. Orient J Chem 2010;26(2).


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Lal H, Aggarwal T. P, Singh V. P, Kumar A. Synthesis of Hydroxy Propyloximino-1-Benzoyl- Indole-2-One Derivatives as Antibacterial and Antifungal Activities. Orient J Chem 2010;26(2). Available from: http://www.orientjchem.org/?p=24082



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