Synthesis, Antibacterial and Antifungal Activities of Some Newer Cephlosporin Derivatives

Neeraj Sharma¹, T. P. Aggarwal¹, Sudhir Kumar Bhati and Ashok Kumar²

¹Department of Chemistry K.G.K P.G College Moradabad (India) ²Medicinal Chemistry Division, Department of Pharmacology L.L.R.M. Medical College, Meerut - 250 04 (India).

7-(D-5-Amino-5-carboxy-valeramido)-3-(acetylhydrazido)-8-oxo-5-thio-1-azabicyclo [4,2,0]-oct-2-ene-2-carboxylic acid (1). 7-(D-5-Amino-5-carboxy-valeramido)-3-(substitutedarylacetylhydrazido)-8-oxo-5-thio-1-azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid.(2-5). 7-(D-5- Amino-5- carboxy- valeramido)- 3- (2'- substituted aryl-3'-chloro-4'-oxo-azetidin-1'-yl)-acetylamino]-8-oxo-5-thio-1-azabicyclo[4,2,0]-oct-2-ene-2-carboxylic acid (6-9). 7-(D-5- Amino-5- carboxy- valeramido)- 3-[(2'-substitutedaryl-4'-oxo-thiazolidin-3'-yl)-acetyl amino]- 8-oxo- 5-thio- 1-azabicyclo [4, 2, 0]- oct-2-ene- 2- carboxylic acid.(10-13) have been synthesized in present study. All the developed congeners of cephalosporin acid evaluated for their antibacterial and antifungal activity. Compound 11 was found to possess potent bactericidal activity in comparison to clinically used chemotherapeutic agents viz. ampicillin; norfloxacin and fluconazole.

Cephlosporin derivatives; Antibacterial and Antimicrobial activities