Hydroxamic Acid as Anticancer Agent

L. K. Tiwary

Regional Institute of Education, National Council of Educational Research Training (NCERT), Shamla Hills, Bhopal (India)

ABSTRACT:

Hydroxamic acids serve as a monsulfhydril bisubstrate analog inhibition of fernesyl protein transferase (FPT), the enzyme catalysing fernesylation of p21ras. Tumor necrosis factor (TFN) is specifically prevented by synthetic hydroxamic acid-based metalloproteinase inhibitors. Suberoyanilide hydroxamic acid (SAHA) have been identified as histone deacetylase inhibitors based on their ability to induce differentiation of cultured murine erytholeukemia cells.

KEYWORDS:

Hydroxamic acid; anticancer agent

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Copy the following to cite this article: Tiwary L. K, Hydroxamic Acid as Anticancer Agent. Orient J Chem 2010;26(2).

Copy the following to cite this URL: Tiwary L. K, Hydroxamic Acid as Anticancer Agent. Orient J Chem 2010;26(2). Available from: http://www.orientjchem.org/?p=24200