Formulation and Evaluation of Simvastatin Floating Tablets

Yadubansh Gupta, Ishrat Alim* and Dabeer Ahmad

¹Department of Pharmacy, Singhania University, Jhunjhunu (Rajasthan). ²Quality Assurance Laboratory, M.P. Council of Science and Technology, Vigyan Bhavan, Science Hills, Nehru Nagar, Bhopal (India).

In the present study we report, the various processing parameters and formulations aspects for developing a pharmaceutical equivalent, stable, cost improved and quality improved formulation of floating tablet of Simvastatin comparable with innovator and optimize certain process parameters to get maximum yield of the product during large scale manufacturing. Being a Class II drug, Simvastatin shows slow dissolution rate, limited oral absorption and high variability in pharmacological effects. Present study has been done for improving the absorption and its bioavailability in order to establish controlled floating drug delivery systems of Simvastatin. Four formulations were prepared by using of HPMC K4M and Ethyl cellulose as polymers and fixed amount of gas generating agent sodium bi carbonate and hydrophobic material bees wax by melt granulation technique and it was noticed that the prepared tablets constantly found to be buoyant for more than 8 hours in the released medium. In vitro drug release, kinetic data and related stability studies after optimization of promising formulation of selected drug are being done to exhibit diffusion dominant drug release and its stability may be attributed to that the present problem certainly will be helpful and surely will open an avenue for new trend of control drug delivery system.

Oral drug delivery system; sustained release of drug; Simvastatin Floating tablets; Buoyancy