Synthesis, characterization and biological activities of some new acid hydrazones

R. N. Sharma, K. P. Sharma* and S. N. Dixit

Chemical Laboratories, Government SMS Science College, Gwalior - 474 002 (India).

ABSTRACT:

A series of new acidhydrazones have been synthesised by the reaction of 2,3-dichloroanilido acetohydrazide with various carbonyl compounds in 58 to 92% yield. Newly synthesized compounds (1,3,4,7,8,9,12,13,15and16) have been tested for their anti-bacterial activity against gram positive bacteria S.albus, S.aureus and Gram negative bacteria E.coli and Pseudomonas piosineus. The compound 1,3,12,13 and 15 shown significant activity and compound 4,7,8 and 9 have shown moderate activity. The same compounds were tested for their anti-fungal activity against Candida albicans, Aspergillus niger and Alternaria alternate at concentration of 30 mg/ml using sabouraud dextrose agar media. Compounds 12,13 and 15 were found to be moderately active against candida albicans and aspergillus niger. All the other compounds did not show significant activity against the fungi at the concentration used.

KEYWORDS:

Malonicester; Acidhydrazide; Accidhydrazones; synthesis; Characterization; and Biological Activities

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Copy the following to cite this article: Sharma R. N, Sharma K. P, Dixit S. N. Synthesis, characterization and biological activities of some new acid hydrazones. Orient J Chem 2010;26(1).

Copy the following to cite this URL: Sharma R. N, Sharma K. P, Dixit S. N. Synthesis, characterization and biological activities of some new acid hydrazones. Available from: http://www.orientjchem.org/?p=11515