Synthesis and Characterization of 2-Mecapto-3-Phenyl-4-Quinazolinone Complexes of Copper (I) : Towards New Copper Radiopharmaceuticals

D. D. Dikshit* and S. B. Singh

Department of Chemistry Jajatpur P.G. College, Jagatpur, Varanasi (India).

2-Mercapto-3-phenyl-4-quinazolinone complexes of copper is synthesized characterized on the basis of chemical properties, elemental data, magnetic susceptibility and characteristic absorption band in IR and ultra-violet absorption frequencies. The structure of complex underline the ability of Cu (I) centre to exist in distorted tetrahedral environment. The binding mode of the ligand is usual and it coordinates monddently through Sulphur. Electrochemical measurement shows that copper complexes undergo a reversible one electron oxidation-reduction reaction at biologically accessible potential.

MPQH; Hypoxia; Thiosemicarbazones