Synthesis, characterisation and biocidal studies of Cu(II) and Co(II) complexes with drug alprazolam [8-chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo (4,3-a) (1,4) benzodiazepine]

Chandra Kant Bhardwaj and R.K. Pandey  

Department of Chemistry, Ganjdundwara (P.G.) College Ganjdundwara, District, Etah, (India)  

ABSTRACT:

In the present study, Cu(II) and Co(II) complexes have been prepared by reacting metal Nitrate with the ligand (Alprazolam), which have the general structural composition [(L) M(NO3)2], where M=Cu(II) and Co(II) and L=Alprazolam [8-chloro-1-methyl-6-phenyl-4H-1,2,4-trizolo (4,3-a) (1,4) benzodiazepine].The complexes were characterised on the basis of elemental analysis, molecular weight and IR data. The shift in the characteristic infrared frequencies of the free ligand bands confirm the coordination. The IR data of the complexes reveal the bidentate nature with [N(1) and N(4)] sites of the ligand. All the complexes, ligand and metal salts have been screened for antibacterial and antifungal activities against selected microbes. Biocidal studies show that the Cu(II) complexes is more effective than Co(II) complexes.

KEYWORDS:

Metal complexes; alprazolam and biocidal study

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Copy the following to cite this article: Bhardwaj C. K, Pandey R. K. Synthesis, characterisation and biocidal studies of Cu(II) and Co(II) complexes with drug alprazolam [8-chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo (4,3-a) (1,4) benzodiazepine]. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Bhardwaj C. K, Pandey R. K. Synthesis, characterisation and biocidal studies of Cu(II) and Co(II) complexes with drug alprazolam [8-chloro-1-methyl-6-phenyl-4H-1,2,4-triazolo (4,3-a) (1,4) benzodiazepine]. Orient J Chem 2009;25(4). Available from: http://www.orientjchem.org/?p=22737