Synthesis and antimicrobial activity of some new 2,5 disubstituted 1,2,4-triazoles  

Prabhu C. Jalihal¹*, Suresh Sharabasappa² and Basavaraj Kilarimath²  

¹Department of Pharmaceutical Chemistry H.S.K.College of Pharmacy Bagalkot - 580 071 (India).

²Department of Pharmaceutical Chemistry KLE’S College of Pharmacy, Vidyanagar, Hubli - 580 031 (India).

ABSTRACT:

Aniline, 4-Chloro aniline, 3,4-dichloro aniline were treated with carbon disulphide and concentrated ammonia in the presence of lead nitrate and methanol to get 1-Phenyl, 4-chlorophenyl, 3,4-dichlorophenylisothiocynates respectively. Ethyl benzoate, methyl salicylate, 4-hydroxy methyl benzoate, 4-amino ethyl benzoate, 2-bromo ethyl benzoate, 4-bromo ethyl benzoate, 3,4-dimethoxy benzoates were treated with hydrazine hydrate(98%) in presence of absolute ethanol to get their respective substituted benzo hydrazides. which are further treated with 1-phenyl, 4-chlorophenyl, 3,4-dichlorophenyl isothiocynates in presence of absolute ethanol to get their respective substituted Thiosemicarbazides.which are undergo dehydrative cyclization with concentrated sodium hydroxide to furnished with corresponding substituted 1,2,4-triazoles.the newly synthesized compounds were characterized by spectral and elemental analysis and the compounds were tested for antimicrobial activity.

KEYWORDS:

Triazole; phenylisothiocynates; benzohydrazide

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Copy the following to cite this article: Jalihal P. C, Sharabasappa S, Kilarimath B. Synthesis and antimicrobial activity of some new 2,5 disubstituted 1,2,4-triazoles. Orient J Chem 2016;25(4).

Copy the following to cite this URL: Jalihal P. C, Sharabasappa S, Kilarimath B. Synthesis and antimicrobial activity of some new 2,5 disubstituted 1,2,4-triazoles. Orient J Chem 2016;25(4). Available from: http://www.orientjchem.org/?p=22745