Syntheses and characterization of some 1, 2, 4-triazole derivatives as biological agents

Ram Janam Singh¹* and Dharmendra Kumar Singh²

¹Quality Control Laboratory, Indian Oil Corporation Limited, Panipat Refinery Panipat, Haryana - 132 140 (India).

²Synthetic Research Laboratory, Department of Chemistry, Veer Bahadur Singh Purvanchal University, Jaunpur - 222 002 (India).

ABSTRACT:

3-Alkyl -4-amino-4, 5-dihydro-1H-1, 2, 4-triazole-5-one (1) when condensed with di-(3-formyl phenyl)-terephthalate (2) yielded the corresponding novel di-[3-(3-alkyl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethinphenyl]-terephthalate (3). All the synthesized compounds were characterized by IR, PMR, Mass spectral data and elemental analyses. All newly synthesized compounds have been assayed for their antibacterial activity against S. aureus, E. coli, B. subtilis and P. aeruginosa

KEYWORDS:

4, 5-dihydro-1H-1, 2, 4-triazole-5-one; di-(3-formyl phenyl)-terephthalate; condensation; cyclization; antibacterial activity

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Copy the following to cite this article: Singh R. J, Singh D. K. Syntheses and characterization of some 1, 2, 4-triazole derivatives as biological agents. Orient J Chem 2009;25(4).

Copy the following to cite this URL: Singh R. J, Singh D. K. Syntheses and characterization of some 1, 2, 4-triazole derivatives as biological agents. Orient J Chem 2009;25(4). Available from: http://www.orientjchem.org/?p=23003